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This review focuses on the emerging evidence that reactive oxygen species ROS derived from glucose metabolism, such as H 2 O 2 , act as metabolic signaling molecules for glucose-stimulated insulin secretion GSIS in pancreatic beta-cells. Particular emphasis is placed on the potential inhibitory role of endogenous antioxidants, which rise in response to oxidative stress, in glucose-triggered ROS and GSIS. We propose that cellular adaptive response to oxidative stress challenge, such as nuclear factor E2-related factor 2 Nrf2 -mediated antioxidant induction, plays paradoxical roles in pancreatic beta-cell function.

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ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function

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X-ray absorption near-edge spectroscopic and X-ray photoelectron spectroscopic data have confirmed that the nickel in the bimetallic nanoclusters is in the zero-valence state, as stabilized by the presence of Pd. The catalytic activities are demonstrated to be dependent on the metal composition of the particles. Corresponding author.

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ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function

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Diffuse reflectance IR spectroscopy along with H 2 and CO adsorption measurements were applied to the study of 0. Reduction of the catalyst at K results in formation of supported metallic Pt particles in SMSI strong metal-support interaction state, as evidenced by the sharp decrease of Pt ability to chemisorb H, at room temperature as well as the significant lowering of thermal stability of linear Pt-CO complexes.

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Perry’s The rushing yards are the most in the history of the Army-Navy game and the most in Navy history against an FBS opponent. He is just the eighth student-athlete to win both awards since and the first since Keenan Reynolds in It is the first time in school history that Navy has had two football players named First-Team Academic All-Americans in the same year.

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